Due to a shoulder injury, Chiefs RB Isiah Pacheco was ruled out of Sunday’s game against the Bills.

One of the Chiefs’ most potent offensive weapons won’t be available to them on Sunday.

The Chiefs confirmed on Friday that running back Isiah Pacheco would not be playing against the Buffalo Bills at home because of a shoulder issue. Pacheco didn’t practice all week before being declared out. He had surgery to repair a torn labrum in the offseason, and he also sustained a bruise to the same shoulder.

Through 12 games (11 starts), the second-year running back has accounted for 57.8% of Kansas City’s rushing attempts (176 carries), accumulating 779 rushing yards and six rushing touchdowns. On Sunday, Clyde Edwards-Helaire, who ranks third in the Chiefs’ carries (14%), behind QB Patrick Mahomes and Pacheco, will be the team’s primary running back.

In a news conference on Friday, head coach Andy Reid declared, “(Edwards-Helaire) is the number one guy.” “He performed admirably. Clyde is a decent young man. When it has come to playing, he has performed admirably.”

Pacheco’s absence against the Bills is also due to injuries to safety Bryan Cook (ankle), offensive lineman Donovan Smith (neck), and linebacker Drue Tranquill (concussion). Reid did not give a schedule for when Cook and Pacheco might return to action.

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When asked if Pacheco and Cook could be placed on injured reserve due to their injuries, Reid responded, “We’ll see.” “I won’t say anything about it since they’re both kind of being reviewed right now, but we’ll have to wait and see.”

Dallas: Following an appendectomy, head coach Mike McCarthy will coach the Cowboys against the Eagles.

Both Mahomes (pectoral) and Bills quarterback Josh Allen (right shoulder) were classified as injured on their respective teams’ injury reports, but after participating in several full practices this week, both are anticipated to play on Sunday.

The Chiefs (8-4) lost 27-19 to the Green Bay Packers last week, and the Bills (6-6) lost 37-34 in overtime to the Philadelphia Eagles in Week 12 prior to their bye week. Both teams are coming off a defeat and are in dire need of a victory.