After a brief two-game road trip, the Philadelphia 76ers will host the Memphis Grizzlies at the Wells Fargo Center on Wednesday night.

They were shorthanded going into Tuesday night’s game against the Brooklyn Nets, as their top scorer, Tyrese Maxey, was out with a concussion after colliding with Derrick Jones Jr. of the Dallas Mavericks on Sunday afternoon.

Maxey wasn’t the only player left out of the game; De’Anthony Melton also missed the game because of back problems that reappeared after he made a brief comeback to the court earlier in the month.

Melton’s reputation as a defensive player is well-established; he has played in 15 games this season with multiple steals and has successfully blocked 16 shots.

Melton and his defensive skills will be unavailable to the Sixers on Wednesday night when they play the Grizzlies, who may also be without their defensive captain.

Due to tendinitis in his right quadriceps, which has kept him out of action since the beginning of the month, former defensive player of the year Jaren Jackson Jr. has been downgraded to questionable for Wednesday night’s action.

Due to Ja Morant’s absence from the Grizzlies for a significant portion of the season—first from a suspension and then from an injury that ended the season—Jackson has emerged as Taylor Jenkins’ go-to scorer, averaging a career-high 22 points per game on 44 percent shooting.

However, this has come at a price: the two-time first-team All-Defensive team member’s average block total has dropped to just 1.5 per game from his previous season. The native of New Jersey is also averaging one steal and five rebounds a game, four of which are defensive.

Jackson is not the only player in Memphis’ starting lineup to be benched against Philadelphia; Yuta Watanabe is out because of a sprain to his right wrist, and Marcus Smart, a former Boston Celtic, is expected to miss the game because of a rupture in his right ring finger.